Entering the 2021-22 season:
| # | School (No. 1 votes) | W-L | Pts. | Prev. |
| 1 | Randolph-Macon (19) | 12-0 | 618 | 1 |
| 2 | Yeshiva (3) | 7-0 | 533 | 3 |
| 3 | Marietta | 12-1 | 496 | 5 |
| 4 | Illinois Wesleyan (1) | 8-1 | 463 | 4 |
| 5 | UW-Platteville | 8-2 | 417 | 9 |
| 6 | Wheaton (Ill.) | 12-1 | 411 | 8 |
| 7 | Trine | 17-1 | 386 | 6 |
| 8 | Swarthmore (1) | 0-0 | 344 | -- |
| 9 | St. Joseph (Conn.) | 2-2 | 316 | -- |
| 10 | Elmhurst | 7-3 | 313 | -- |
| 11 | Tufts | 0-0 | 282 | -- |
| 12 | Mary Hardin-Baylor | 16-4 | 280 | -- |
| 13 | Emory | 0-0 | 278 | -- |
| 14 | Johns Hopkins | 0-0 | 276 | -- |
| 15 | UW-La Crosse | 8-3 | 261 | 13 |
| 16 | Dubuque | 14-0 | 250 | 7 |
| 17 | UW-Oshkosh | 5-2 | 235 | 12 |
| 18 | Washington U. | 0-0 | 224 | -- |
| 19 | Whitworth (1) | 12-5 | 214 | 14 |
| 20 | Roanoke | 10-2 | 159 | -- |
| 21 | Mount Union | 8-4 | 157 | -- |
| 22 | Wittenberg | 1-7 | 101 | -- |
| 23 | Maryville (Tenn.) | 10-2 | 96 | -- |
| 24 | New Jersey City | 7-1 | 92 | 15 |
| 25 | Brandeis | 0-0 | 85 | -- |
Others receiving votes: St. John's 69; Berry 61; Colby 57; Rochester 50; RPI 49; Virginia Wesleyan 47; DeSales 46; Linfield 43; Christopher Newport 38; Buena Vista 38; Amherst 37; Brockport 37; DePauw 32; WPI 25; Pacific Lutheran 21; St. John Fisher 19; North Central (Ill.) 18; Pomona-Pitzer 17; Heidelberg 13; Trinity (Texas) 13; Nebraska Wesleyan 11; Centenary (La.) 10; Middlebury 9; TCNJ 9; St. Mary's (Minn.) 9; Babson 8; Wooster 8; Lynchburg 8; Albion 7; Springfield 7; Stevens 7; Ithaca 5; Wabash 3; Ripon 2; Centenary (N.J.) 1; Hendrix 1; Lycoming 1; Utica 1; Williams 1.
The D3hoops.com Top 25 is voted on by a panel of 25 coaches, Sports Information Directors and media members from across the country, and is published weekly. Points are awarded on a 25-24-23-22-etc. basis.